American College of Rheumatology 20/50/70 criteria (ACR20/50/70)

Felson DT; Pincus T

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Basic description

Developed in 1993

The ACR20 is a composite measure defined as both improvement of 20% in the number of tender and number of swollen joints, and a 20% improvement in three of the following five criteria: patient global assessment, physician global assessment, functional ability measure [most often Health Assessment Questionnaire (HAQ)], visual analog pain scale, and erythrocyte sedimentation rate or C-reactive protein (CRP).

ACR50 and ACR70 are the same instruments with improvement levels defined as 50% and 70% respectively versus 20% for ACR20


Felson DT; Pincus T

Pincus T for the patient assessment (adapted from the MHAQ)
Physician Assessment Form © 1999, American College of Rheumatology.
To evaluate pain / patients’ general health condition upon arthritis
Therapeutic area
  • Skin and Connective Tissue Diseases
  • Musculoskeletal Diseases
  • Immune System Diseases
Therapeutic indication

Arthritis, Rheumatoid

Type of Clinical Outcome Assessment (COA)
  • Composite measures Composite measures
PRO and ClinRO - Composite measure including biomarkers
Original language(s)
  • English for the USA
Bibliographic reference(s) of the original questionnaire

Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, Furst D, Goldsmith C, Kieszak S, Lightfoot R, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials. Arthritis Rheum. 1993 Jun;36(6):729-40 (PubMed Abstract)

Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, Katz LM, Lightfoot R Jr, Paulus H, Strand V, et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6):727-35 (PubMed Abstract)

Last update: February 2016
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