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Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS)

Cedarbaum JM; Stambler N; Malta E; Fuller C; Hilt D; Thurmond B; Nakanishi A

ProQolid

Basic description

The ALSFRS was developed in 1991 for use in clinical trials of new therapeutic agents for amyotrophic lateral sclerosis (ALS).

The Revised version (ALSFRS-R) was introduced in 1999 to gather additional information related to sleeping and breathing. 

Authors

Cedarbaum JM; Stambler N; Malta E; Fuller C; Hilt D; Thurmond B; Nakanishi A

Copyright
Public domain
Objective
To monitor the progression of disability in patients with amyotrophic lateral sclerosis. The scale measures physical function in carrying out activities of daily living (ADL).
Therapeutic area
  • Nervous System Diseases
  • Nutritional and Metabolic Diseases
  • Rare disease (Orphanet definition)
Therapeutic indication

Amyotrophic Lateral Sclerosis For more information on this rare disease, please consult the following link: Orphanet page

Type of Clinical Outcome Assessment (COA)
  • clinro ClinRO
Original language(s)
  • English for the USA
Translations
4 translation(s)
Bibliographic reference(s) of the original questionnaire

ALSFRS

The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II Study Group. Arch Neurol. 1996 Feb;53(2):141-7 (PubMed Abstract)

Cedarbaum JM, Stambler N. Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials. J Neurol Sci. 1997 Oct;152 Suppl 1:S1-9 (PubMed Abstract)

ALSFRS-R

Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A.  The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999 Oct 31;169(1-2):13-21 (PubMed Abstract)

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