The ALSFRS was developed in 1991 for use in clinical trials of new therapeutic agents for amyotrophic lateral sclerosis (ALS).
The Revised version (ALSFRS-R) was introduced in 1999 to gather additional information related to sleeping and breathing.
Cedarbaum JM; Stambler N; Malta E; Fuller C; Hilt D; Thurmond B; Nakanishi A
Amyotrophic Lateral Sclerosis For more information on this rare disease, please consult the following link: Orphanet page
The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II Study Group. Arch Neurol. 1996 Feb;53(2):141-7 (PubMed Abstract)
Cedarbaum JM, Stambler N. Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials. J Neurol Sci. 1997 Oct;152 Suppl 1:S1-9 (PubMed Abstract)
Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999 Oct 31;169(1-2):13-21 (PubMed Abstract)