Disease Activity Score - Erythrocyte Sedimentation Rate (DAS / DAS-28 ESR)

van Riel PL

Distributed by Mapi Research Trust


Distributed by Mapi Research Trust

Basic description

Original DAS: Developed in 1983

DAS-28: Developed in 1995

A another version with a different scoring exists: DAS-28 CRP

DAS and DAS-28 differ in joint counts

WEBINAR: An Author Webinar on the Disease Activity Score - Recorded session available here!

As the DAS includes both clinical and patient assessments, only patient assessment is described below


van Riel PL

DAS-28 © Piet Van Riel, 1995.
To judge disease activity in clinical practice
Therapeutic area
  • Skin and Connective Tissue Diseases
  • Musculoskeletal Diseases
  • Immune System Diseases
Therapeutic indication

Arthritis, Rheumatoid

Type of Clinical Outcome Assessment (COA)
  • Composite
PRO, ClinRO and Biomarkers
Original language(s)
  • English for the UK
Bibliographic reference(s) of the original questionnaire

Prevoo, M. L., van 't Hof, M. A. , Kuper, H. H. , van Leeuwen, M. A. , van de Putte, L. B. , van Riel, P. L. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38;1: 44-8. (Full text article)

Prevoo, M. L. , van Riel, P. L. , van 't Hof, M. A. , van Rijswijk, M. H. , van Leeuwen, M. A. , Kuper, H. H. , van de Putte, L. B. Validity and reliability of joint indices. A longitudinal study in patients with recent onset rheumatoid arthritis. Br J Rheumatol. 1993;32;7: 589-94. (PubMed abstract)

Prevoo, M. L. , van Gestel, A. M. , van, T. Hof M. A. , van Rijswijk, M. H. , van de Putte, L. B. , van Riel, P. L. Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatism Association preliminary remission criteria in relation to the disease activity score. Br J Rheumatol. 1996;35;11: 1101-5. (PubMed abstract)

van der Heijde DM, van't Hof MA, van Riel PL, van Leeuwen MA, van Rijswijk MH, van de Putte LB. Validity of single variables and composite indices for measuring disease activity in rheumatoid arthritis. Ann Rheum Dis. 1992 Feb;51(2):177-81 (Full text article)

van der Heijde DM, van 't Hof MA, van Riel PL, Theunisse LA, Lubberts EW, van Leeuwen MA, van Rijswijk MH, van de Putte LB. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis. 1990 Nov;49(11):916-20 (Full text article)

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van Riel PL

Prof. dr. Piet L.C.M. van Riel
Principle Investigator

Piet L.C.M. van Riel Publications (PubMed)

Contact information

Mapi Research Trust
27 rue de la Villette
69003 Lyon
Phone: +33 (0)4 72 13 66 66

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  • English for the UK


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