Developed in 1987
Composed of a generic CORE questionnaire, the Functional Assessment of Cancer Therapy-General FACT-G, complemented with FACIT scales addressing relevant disease-, treatment-, or condition-related issues not covered in the general questionnaire.
There are over 40 different FACIT scales with a unique name and acronym corresponding to the targeted issue, and nine symptom indices available for select tumor sites.
The Trial Outcome Index can be computed for any FACIT disease-, treatment-, or condition-specific scale. It is the sum of the Physical Well-Being (PWB), Functional Well-Being (FWB), and "additional concerns" subscales. The TOI is an efficient summary index of physical/functional outcomes. It is a common endpoint used in clinical trials.
Cancer-specific measures described in PROQOLID:
Lung cancer: FACT-Lung
Hepatobiliary cancer: FACT-Hep
Breast cancer: FACT-B
Prostate cancer: FACT-P
Treatment-specific measures described in PROQOLID:
For patients receiving Biologic Response Modifiers: FACT-BRM
Symptom-specific measures described in PROQOLID:
Fatigue: FACIT-F and FACIT-Fatigue
For patients with Anemia/Fatigue: FACT-An
Non-Cancer specific measure described in PROQOLID:
Functional Assessment of Multiple Sclerosis: FAMS
Cella DF, Tulsky DS, Gray G, et al. The Functional Assessment of Cancer Therapy (FACT) scale: Development and validation of the general measure. Journal of Clinical Oncology 1993, 11(3), 570-579 (PubMed abstract)
Webster, K., Odom, L., Peterman, A., Lent, L., Cella, D. The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: Validation of version 4 of the core questionnaire. Quality of Life Research 1999, 8(7):604