Mayo Score (Mayo)

Schroeder KW; Tremaine WJ; Ilstrup DM


Last update: September 2021

Basic description

  • Published in 1987
  • A Modified Mayo Disease Activity Index (MMDAI) was published in 2008

Schroeder KW; Tremaine WJ; Ilstrup DM

© Mayo Clinic
The Mayo Score aims to assess the severity of Ulcerative colitis. It is a composite of subscores from four categories, including stool frequency, rectal bleeding, findings of flexible proctosigmoidoscopy or colonoscopy, and physician’s global assessment.
Therapeutic area
  • Digestive System Diseases
Therapeutic indication

Colitis, Ulcerative

Type of Clinical Outcome Assessment (COA)
  • Composite
PRO and ClinRO
Original language(s)
  • English for the USA
Bibliographic reference(s) of the original questionnaire

Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317:1625–29 (PubMed abstract)

Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands  BE, Colombel JF. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005 Dec 8;353(23):2462-76. Erratum in: N Engl J Med. 2006 May 18;354(20):2200. (PubMed Abstract)