Michigan Neuropathy Screening Instrument (MNSI)

Brown MB; Feldman EL; Funnell MM; Greene DA; Stevens MJ

Distributed by Mapi Research Trust


Distributed by Mapi Research Trust

Basic description

  • Published in 1994

The Michigan Neuropathy Screening Instrument (MNSI) is designed to screen for the presence of diabetic neuropathy. The MNSI is designed to be used in an outpatient setting by primary care or other providers

The first part of the screening instrument, the history questionnaire, consists of 15 self-administered "yes or no" questions on foot sensation including pain, numbness and temperature sensitivity. A higher score (out of a maximum of 13 points) indicates more neuropathic symptoms

The questions were chosen from among those in the Neuropathy Screening Profile of Peter Dyck that showed the highest degree of specificity and sensitivity for diabetic neuropathy among normal subjects and those with a variety of neuromuscular disorders (Neurology, 36:1300-1308, 1986)

The second part of the MNSI is a brief physical assessment (completed by health professionals) involving
1) inspection of the feet for deformities, dry skin, hair or nail abnormalities, callous or infection
2) semi-quantitative assessment of vibration sensation at the dorsum of the great toe
3) grading of ankle reflexes and
4) monofilament testing.
Patients screening positive on the clinical portion of the MNSI (greater than 2 points on a 10 point scale) are considered neuropathic and referred for further evaluation


Brown MB; Feldman EL; Funnell MM; Greene DA; Stevens MJ

MNSI, © University of Michigan, 2000
Designed to screen for the presence of diabetic neuropathy
Therapeutic area
  • Nutritional and Metabolic Diseases
  • Endocrine System Diseases
Therapeutic indication

Diabetes Mellitus

Diabetic neuropathy
Type 1 - IDDM, Type 2 - NIDDM
Type of Clinical Outcome Assessment (COA)
  • Composite
PRO and ClinRO
Original language(s)
  • English for the USA
Bibliographic reference(s) of the original questionnaire

Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA: A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care 1994;17:1281-1289 (PubMed Abstract)

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Contact and conditions of use


Brown MB; Feldman EL; Funnell MM; Greene DA; Stevens MJ

Contact at Michigan Diabetes Research Center:
Pam Campbell
Michigan Center for Diabetes Translational Research
University of Michigan Medical School
1000 Wall Street, RM# 6100
Brehm  Tower
Ann Arbor, Michigan 48105
Phone: 734-763-5730
Fax: 734-647-2307
E-mail: pamcamp@med.umich.edu

Contact information

Mapi Research Trust
27 rue de la Villette
69003 Lyon
Phone: +33 (0)4 72 13 66 66

Conditions of use

Distribution of Translations

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Original version

The original English version is freely available for download in the Michigan Diabetes Research Center (MDRC)’s website.

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Original language(s)

  • English for the USA


The list of available translations is subject to constant changes and may not be exhaustive. It is provided for information only. Some recently produced translations may not be included in the list below yet. Please do check the status of available translations with Mapi Research Trust / the developers / copyright holders / distributors.

Also, the listed translations may not have undergone a full linguistic validation process and may require further work to be suitable for use in a study.


Czech for Czech Republic*
Finnish for Finland
French for France*
German for Austria*
Hungarian for Hungary*
Portuguese for Portugal
Spanish for the USA* L
Turkish for Turkey
* Performed by Mapi/ICON
L Has undergone a Linguistic Validation methodology

Conditions to translate

Recommended vendor for translation work: Mapi/ICON Language Services

The user can translate the instrument and special permission from Owner is not needed.
User shall send a copy of the translations to the Owner when completed.

Also, the Owner asks that user cites their Center: "The project described was supported by Grant Number P30DK020572 (Michigan Diabetes Research Center (MDRC)) from the National Institute of Diabetes and Digestive and Kidney Diseases" Or “The project described was supported by Grant Number P30DK092926 (Michigan Diabetes Research Center (MDRC)) from the National Institute of Diabetes and Digestive and Kidney Diseases.”

More information on translations

Bibliographic references of the translations:

Jia WP, Shen Q, Bao YQ, Lu JX, Li M, Xiang KS. [Evaluation of the four simple methods in the diagnosis of diabetic peripheral neuropathy] Zhonghua Yi Xue Za Zhi. 2006 Oct 17;86(38):2707-10. Chinese (PubMed abstract)
Barbosa M, Saavedra A, Severo M, Maier C, Carvalho D. Validation and Reliability of the Portuguese Version of the Michigan Neuropathy Screening Instrument. Pain Pract. 2017 Apr;17(4):514-521 (PubMed abstract)
Aktar Reyhanioğlu D, Adiyaman SC, Bektaş M, Bulut O, Özgen Saydam B, Bayraktar F, Kara B. Turkish validity and reliability of the Michigan Neuropathy Screening Instrument. Turk J Med Sci. 2020 Mar 17;50(4):789–97 (Full text article)

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