Patient Health Questionnaire (PHQ)

Kroenke K; Spitzer RL; Williams Janet BW


Basic description

The PHQ, the self-administered version of the PRIME-MD, contains the mood, anxiety, alcohol, eating, and somatoform modules as covered in the original PRIME-MD.
The PHQ-9 (specific to depression) simply scores each of the 9 DSM-IV criteria based on the mood module from the original PRIME-MD.
The PHQ-15 was derived from the original PHQ studies and is increasingly  used  to  assess  somatic  symptom  severity  and  the  potential  presence  of  somatization and somatoform disorders


Kroenke K; Spitzer RL; Williams Janet BW

The names PRIME-MD, Prime-MD Today, Prime MD for Today’s Patient and Patient Health Questionnaire (PHQ) are trademarks of Pfizer Inc. © 1999, Pfizer Inc. All rights reserved. Reproduced with permission
For the assessment of mental disorders, functional impairment, and recent psychosocial stressors
Therapeutic area
  • Mental Disorders
  • Behavior and Behavior Mechanisms
Therapeutic indication
  • Anxiety Disorders
  • Alcohol Drinking
  • Feeding and Eating Disorders
Type of Clinical Outcome Assessment (COA)
  • pro PRO
  • Composite
PRIME-MD: Composite measure: PRO/ClinRO
Original language(s)
  • English for the USA
124 translation(s)
Bibliographic reference(s) of the original questionnaire

- PHQ-15

Kroenke K, Spitzer RL, Williams JB. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med. 2002 Mar-Apr;64(2):258-66 (PubMed Abstract)

- PHQ-9
Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 (PubMed Abstract)

- PHQ (PRIME-MD Self-administered version)
Spitzer RL, Williams JB, Kroenke K, Hornyak R, McMurray J. Validity and utility of the PRIME-MD patient health questionnaire in assessment of 3000 obstetric-gynecologic patients: the PRIME-MD Patient Health Questionnaire Obstetrics-Gynecology Study. Am J Obstet Gynecol 2000; 183:759-69 (PubMed Abstract)

Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 1999; 282:1737-44 (Pubmed Abstract)

- PRIME-MD (Computer- and clinician-administered versions)
Kobak KA, Taylor LH, Dottl SL, Greist JH, Jefferson JW, Burroughs D, Mantle JM, Katzelnick DJ, Norton R, Henk HJ, Serlin RC. A computer-administered telephone interview to identify mental disorders. JAMA. 1997 Sep 17;278(11):905-10 (PubMed Abstract)

- PRIME-MD (Clinician-administered version)
Spitzer RL, Williams JB, Kroenke K, Linzer M, deGruy FV 3rd, Hahn SR, Brody D, Johnson JG. Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA. 1994 Dec 14;272(22):1749-56 (PubMed Abstract)

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